DIVAccounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening hits as well as rational, structure-based design. The chapters include follow-ons and next generation compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly f
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